Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.

Deoxyribonucleic acid double-stranded breaks act as intermediates in Ig V(D)J recombination and probably perform a similar function in class switch recombination between IgH C genes. In SCID mice, V(D)J recombination is blocked because the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein is defective. We show in this study that switching to all isotypes examined was detectable ...

Rare Absence of CD79alpha in B-ALLs is not Associated with Altered Prognosis

Background: The diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) on the basis of the World Health Organization (WHO) recommendations in 2016 requires the expression of CD19 with CD79a (CD79a), cCD22 and CD10. CD79a is an integral B cell antigen expressed at all stages. Its absence in B-ALL has only been rarely reported. In this study, we described three cases of B-ALL showing complete l...

Somatic Mutation , and Isotype Switching During a Memory B

Aprimary humoral immune response to most antigens results in the development of a long-lasting state of immunity. In addition to influencing the outcome of a secondary immune response to the priming antigen, this state of immunity may also alter subsequent immune responses to antigens that are structurally related to this priming antigen, a phenomenon that has been termed "original antigenic si...

Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation.

Giant cell glioblastoma (gcGB), a subtype of GB, is characterized by the presence of numerous multinucleated giant cells. The prognosis for gcGB is poor, but it may have a better clinical outcome compared with classic GB. The molecular alterations that lead to the multinucleated cell phenotype of gcGB have not been elucidated. Giant cell GB has a higher frequency of the tumor suppressor protein...

Isotype Switching by Human B Cells Is